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A new look at old diseases

Modern everyday life is rich in stress states, and the chance to acquire stress has steadily increased due to rapid environmental changes, chronic fatigue, complicated personal relationships and tense psychological situation which occur more often now.

One of the most common complaints that forces people to go to the doctor is fatigue, which is called differently: weakness, fatigue, languor, lack of energy. When you are exhausted because of usual activities, you suffer from fatigue and reasons for that can be diverse. As a consequence you get a weakened body and the development of various diseases.

Among them are the cardiovascular system diseases, infectious diseases causing chronic fatigue syndrome, respiratory problems such as emphysema or sleep apnea (a condition in which people cannot breathe properly during sleep, and therefore they have a bad sleep), anemia, chronic disease and, finally, various disorders of the nervous system.

The weakening of the functions and operability of the immune and nervous systems of the body are “triggers “ in the development of diseases of almost all organs and systems of our body, not the exception is the pathology of the gastrointestinal tract (GIT). The most common diseases of the digestive tract connected with the violation of acidity are gastritis, gastroduodenitis, gastric ulcer and duodenal ulcer. These diseases can have both acute and chronic forms with seasonal exacerbations.

In recent years the number of people suffering from gastric ulcer and duodenal ulcer has increased greatly. At present different anti-ulcer preparations have been developed and are widely used. Anti-ulcer drugs which have been used so far can be classified into groups: preparations inhibiting the release of digestive enzymes and their activity, preparations that inhibit gastric acid secretion; preparations promoting repairation and protection of the tissues of the mucous membranes, etc. These drugs are prescribed for oral taking or subcutaneous injections. However, these drugs either have a unilateral action, or are synthesized drugs, each of which has its side effects, so the limitations associated with their taking and quantities have become particularly noticeable. At the same time, an effective and safe antiulcer agent has not yet been developed and applied. Thus many specimens of this group have a number of side effects. For example, the application of Cimetidine (antiulcer drug of the first generation) is accomplished with a high risk of developing gynecomastia (breast enlargement in men), much less gynecomastia develops while the application of the next generation of drugs - Ranitidine, etc. Rarely, but still possible, gynecomastia can be developed while application of Omeprazole. In addition, this group of drugs also affects the sexual function of men suppressing male hormones - androgens. Thus, for reasons of safety and prevention of recurrence of these diseases traditional drugs for anti-ulcer cannot be used regularly.

On the other hand, to prevent ulcer the drugs for treating disorders of the intestine are used as well as preparations inhibiting only the secretion of gastric juice. Consequently, they cannot be attributed to the aforementioned preventive anti-ulcer drugs in the true sense of the word. Currently, side effects become a problem for people, and therefore there is a need to develop preparations having anti-ulcer effect, and they are natural products which have no side effects and are quite safe even when used regularly as a preventive preparation, or for prevention of disease recurrence.

Among the main preparations for treatment of digestive diseases associated with disturbance of acid are antacids and anti-ulcer drugs.

Recent years are characterized by a rapid development of a new field of knowledge which is called Pharmaconutritiology and which is a border between the science of Nutrition and Pharmacology. Prerequisites for the development of this science are, first of all, the success of Nutritiology itself, and secondly, the success of Bioorganic Chemistry and Biotechnology, which allowed to obtain a sufficiently purified form of biologically and pharmacologically active components from virtually any active sediment (microorganisms, plants, animals), and thirdly , the success of pharmacological complex, which have studied the mechanisms of action and features of the biotransformation of many natural compounds and created new technologies for their effective dosage forms. Economic aspect is also important because the path from the opening of the active molecule to creating a medicine is too expensive and lengthy. Considerably shorter, cheaper and in some cases no less effective is the detection of the expressed biological activity in active sediment and the creation of biologically active additives (BAAs). Finally, it should be emphasized that there is a part of the population with subjective, psychological factors - they treat negatively everything that is artificial and synthetic, and they are afraid of "chemistry" and, conversely, they unconsciously believe in the power of nature, the so-called natural products, drugs and old recipes.

Development of dietary additives in Ukraine today is very timely in view of the current environmental situation. Therefore, dietary supplements, raw materials for which are created by nature itself to nourish and treat people, are the best preparations for preventing and treating diseases of the century, such as atherosclerosis, diabetes, obesity, gastric ulcer and duodenal ulcer, cancer and many others.

Market of additives in Ukraine is quite promising. Domestic consumers need affordable supplements of good quality. It should be noted the growing interest of the public to natural preventive means to strengthen health. Particularly noteworthy are the plants that have been applied for centuries in folk medicine and gained international fame thanks to their unique properties. These plants include broccoli (Brassica oleracea L. var italica Plenck cabbage family Brassicaceae), which is cultivated throughout the territory of Ukraine and has a sufficient resource base.

Broccoli is used as a dietary product and is a part of the imported mono-and multi-additives. That’s why we consider broccoli to be a promising source of substances for creating special food products of domestic manufacturing with a broad spectrum of action.

Import manufacturers of additives on the basis of broccoli provide its young shoots or inflorescence as a feedstock but that is not very profitable, because the main green mass of plants is not used. With the aim of comparative analysis we have conducted phyto-chemical study of inflorescences and leaves of broccoli. We used different sorts of broccoli which are the most popular in cultivation: Tonus, Romanesco, Vitamins, Kalabrayze and Linda. The quantitative content of macro-and micronutrients was ascertained by atomic adsorption spectroscopy: the plant largely accumulates potassium, sodium, calcium, silicon and phosphorus. A study of the amino acid composition revealed the presence of 16 free and bound amino acids, of which 8 are indispensable. Aspartic and glutamic acids, proline, glycine, arginine, lysine, histidine, phenylalanine, threonine and serine are in the largest amounts. The quantitative content of flavonoids, total oxidation of polyphenols, ascorbic, hydroxycinnamic acids and organic acids, polysaccharides, pectins was determined; and special attention was paid to specific groups of biologically active substances (BAS) of Broccoli - izotiocionats, thiocyonates, which belong to the class of glucosinolates and sulfur-containing glycosides.

The pharmacological effects of broccoli glucosinolates include: antioxidant and antiproliferative activities, harmonization of estrogen metabolism, the activation of the function of recognition of tumour cells by the immune system which help prevent the development of malignant tumours of the lung, stomach, colon, prostate and breast, including estrogen-dependant and which is used in the treatment of precancerous diseases of these organs (mastitis, cysts, adenomas, polyps, etc.) and for revitalization of the immune system as a whole.

Glucosinolates are substance number one in the fight against cancer. Many foreign and local studies confirm a direct correlation between the consumption of glucosinolates and low risk for the above-mentioned cancers. An antiviral effect of glucosinolates on human papillomatosis virus and anti-proliferative effect for tumours caused by these viruses has also been determined.

Glucosinolates and indole compounds of broccoli have another extremely important pharmacological action – anti-Helicobacter pylori effect. For a long time a major role in the occurrence of peptic ulcer disease was attributed to hydrochloric acid. Carl Schwartz wrote in 1910 "No acid - no ulcer". However the hypothesis that the etiological agent of gastric ulcers can be a microorganism appeared more than 100 years ago. In the early 80-ies of the XX century Barry Marshall and Robin Warren (Australia) began systematic studies of the micro-flora of the stomach and soon they found on the surface of epithelium under a layer of mucus a small curved stick covered with a smooth shell and having 5 flagella.

This microbe was called Campylobacter pyloridis. After that they began to isolate this bacterium in all persons with duodenal ulcer and in 75% of patients with gastric ulcer.

Soon the discovery made by B. Marshall was confirmed by other researchers. However, to prove the etiologic role of Campylobacter pyloridis in the origin of peptic ulcer disease was not enough because of the lack of another important fact, namely, the experimental reproduction of disease. Since the relevant experimental models were not known then, B. Marshall had to resort to self-infection and drink a solution with the culture obtained from a 65-year-old patient with chronic gastritis. The dyspeptic symptoms appeared on the 7th day, and on the 10th day after infection endoscopic signs of gastritis were determined. Thus, the issue was completely resolved.

Subsequently the specific name of the new microbe has been changed, and it became known as Campylobacter pylori, and in 1989 it was singled out as a separate genus - Helicobacter.

Polysaccharides of broccoli have anti-toxic properties, it is particularly important when we suffer from the negative impacts of urban smog, cigarette smoke and tap water, as well as when we have intoxication due to severe illness, poisoning, chemotherapy and radiotherapy, use of drugs, chemical action, anesthesia - that is, direct damaging effect on liver cells, the after-effects of chronic diseases, hormonal disorders, which entail the risk of developing tumours.

Thus, as a result of phyto-chemical studies it has been shown that the qualitative composition and quantitative content of inflorescence and leaves of the studied cultivars of broccoli are nearly identical, so we suggest using grass broccoli as a raw material for the development of dietary supplements.

In contrast to foreign manufacturers of special food products based on the broccoli, who use the chopped raw material (usually in capsules), the aim of our work was to extract the maximum amount of biologically active substances from raw materials to obtain the extract and to develop dosage forms.

As an extractant to obtain the extract there was used water that is accessible, environmentally safe and cheap and provides an opportunity to extract a much larger amount of BAS (biologically active substances).

Tablets with an extract of broccoli have been received and are currently produced on the basis of Experimental Plant “GNCLS, Ltd.” – a Pharmaceutical plant specialized in developing industrial technologies of drug products, as well as the production of medicines of high quality for sale on the domestic market of Ukraine and abroad in CIS.

Recently the company expanded its range and has been manufacturing additives, because of the desire to keep pace with the times, carry out the desires and needs of the consumer.

A dietary "Tablets with an extract of broccoli" additive is recommended for the following purposes:

  • for rationalization of nutrition, namely, for the most rapid filling up the deficit of dietary bioactive substances the consumption of which is reduced, as well as for choosing the most optimal balance of nutrients and energy substances for each person, taking into account sex, age, energy, physiological needs, which are responsible for the basic principles of the modern concept of balanced nutrition;
  • for increasing the body's resistance to adverse environmental factors;
  • for prevention of disorders of metabolism and of related chronic diseases;
  • for directional change of metabolism, binding, and rapid excretion of toxic and foreign substances, free radicals;
  • for restoration of reduced immune system;
  • for implementation of the regulation of body functions in the physiological limits. Antioxidants, limiting the effects of free radicals in the cell wall, ensure the normal functioning of various organs and systems, improve the quality of life both while a person being ill as well as they have a powerful preventive effect.

The range of applications of "Tablets with an extract of broccoli" is fairly broad: maintaining the functional state of the digestive tract and digestive processes, prevention of relapse diseases of this system of organs, especially of acid-dependant - gastric ulcer and duodenal ulcer, including the associated Helicobacter pylori, prevention of cancer of the digestive tract , prostate cancer in men and female sex sphere, endometriosis (in the complex treatment), mastopathy and as a general tonic preparation.

Caution in use: increased sensitivity to the individual components of the product, pregnancy, lactation (clinical research in this area was not conducted, contraindications have not been established from the sources of scientific literature).

Recommendation for use: adults and children over 14 years: 1 tablet 3 times a day during meals for 1-2 months.

The ultimate goal of using a dietary additive "Tablets with an extract of broccoli" is improvement of the nutritional status of people, health strengthening, prevention of diseases and supportive treatment of various pathological conditions and regulation of activity of the organism within the boundaries of functional activity.

Schopenhauer said: "Ten tenth of our happiness depends on health”, and we wish you be healthy and therefore happy!